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Activated Signal Transduction Kinases Frequently Occupy Target Genes

Study Design

Data Insights Supplemental Material

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Are the TAP tags inserted into the right gene in the genome?

Is enrichment over actively transcribed genes due to non-specific binding of proteins to the immunoprecipitation reagents?

Is the TAP tag itself responsible for the enrichment over actively transcribed genes (due to, for example, TAP tag binding to the transcription apparatus)?

Do all tagged signaling proteins in the nucleus show occupancy over actively transcribed genes?

Are some of the TAP-tagged proteins functionally impaired and therefore show an artificial binding pattern?

 
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