Activated Signal Transduction Kinases Frequently Occupy Target Genes
Study Design
Data
Insights
Supplemental Material
Acknowledgements
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Is the TAP tag itself responsible for the enrichment over actively transcribed genes (due to, for example, TAP tag binding to the transcription apparatus)?

We compared the results from TAP-tagged strains (red) with those from corresponding MYC-tagged strains (blue). There was no discernible difference between the results from the two strains. The ChIP-chip data from TAP- and MYC-tagged transcription factor Fhl1p during growth in YPD medium at highly transcribed genes are shown as examples. We conclude that the results that we observe for the TAP-tagged proteins are also observed with other tags.
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