Activated Signal Transduction Kinases Frequently Occupy Target Genes
Protein Kinase A
The observation that at least 3 of the 5 yeast MAPKs occupy their target genes upon activation of their cognate signaling pathways led us to investigate whether kinases associated with another type of signaling pathway, the cAMP-activated protein kinase A (PKA) pathway, exhibit similar behavior. In yeast, the 3 catalytic subunits Tpk1p, Tpk2p and Tpk3p are stimulated by increases in cAMP levels when fermentable carbon sources such as glucose are introduced (Thevelein and de Winde 1999; Schneper et al. 2004).