Environment-specific utilization of the transcriptional regulatory code. Four patterns of genome-wide binding behavior are depicted in a graphic representation on the left, where transcriptional regulators are represented by a coloured circle, a representative set of gene/promoters is represented above in the centre, and lines between the regulator and the gene/promoters represent binding events. Specific examples of the environment-dependent behaviors are depicted on the right. Colored circles represent regulators and coloured boxes represent DNA binding sequences present within promoter regions.
A spreadsheet containing more information on the data used to create these classifications is available here.
We discuss in more detail the known regulatory mechanisms for Leu3, Msn2, Gcn4 and Ste12.