Genome-wide Expression Analysis

  

The transcriptional regulatory circuitry of yeast and human cells is being deduced through the use of high density oligonucleotide arrays. We are exploring the role of the transcription apparatus, chromatin and signaling pathways in regulation of genome expression.

Yeast:
	Transcripton apparatus: Holstege, et al. (1998) Dissecting the Regulatory Circuitry of a Eukaryotic Genome.    Kobor, et al. (1999) An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae.    Lee, et al. (2000) Redundant Roles for the TFIID and SAGA Complexes in Global Transcription.    Geisberg, et al. (2001) Yeast NC2 Associates with the RNA Polymerase II Preinitiation Complex and Selectively Affects Transcription In Vivo.
	Chromatin: Wyrick, et al. (1999) Chromsomal Landscape of Nucleosome-dependent Gene Expression and Silencing in Yeast.
	Environmental Changes: Causton, et al. (2001) Remodeling of Yeast Genome Expression in Response to Environmental Changes.
	Signal Transduction: Robertson, et al. (2000) The Yeast A Kinases Differentially Regulate Iron Uptake and Respiratory Function.
Human:
	Macrophage Infection by Bacterial Pathogens: Nau, et al. (2002) Human Macrophage Activation Programs Induced by Bacterial Pathogens.

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