DNA Binding Site Sequences

Experimental procedure. Data from location analysis experiments were subjected to computational analyses to determine regulator binding site sequence specificities. These sequences were compared to and supplemented with published sequence specificities. Phylogenetic conservation information was used both to determine, in part, the binding specificities of regulators and in selecting the set of final sequences for inclusion in the map of the regulatory code. More information can be found here.

Specificity models that were “rediscovered” using our location data (left) as well as newly discovered sequences (right). The height of the each letter is proportional to the probability of observing that nucleotide at that position.