Novel Vaccines
Stress
Protein Fusion Vaccines
The observation that stress proteins have profound immune
stimulatory properties has led us to study their role in immunity and
their potential as vehicles for vaccine delivery.
- Huang, Q., Richmond, J.F.L., Suzue, K., Eisen, H.N. and Young,
R.A. 2000
Elicitation of CTLs by Mycobacterial hsp70 Fusion Proteins Maps to
a Discrete Domain and is CD4+ T Cell-Independent. J. Exp. Med.,
191:403-408.
- Suzue, K., Zhou, X., Eisen, H. and Young, R.A. 1997. Heat
shock fusion proteins as vehicles for antigen delivery into the
MHC class I presentation pathway. Proc. Natl. Acad. Sci. USA,
94:13146-13151.
- Suzue, K. and Young, R.A. 1996. Adjuvant-free hsp70 fusion
protein system elicits humoral and cellular immune responses to
HIV-1 p24. J. Immunol. 156: 873-879.
M. bovis BCG vaccine vehicle
We have also developed a live recombinant mycobacterial vaccine
vehicle that is being investigated for its efficacy against a variety
of infectious diseases and cancer.
- Tsenova, L., Bergtold, A., Freedman, V.H., Young, R.A. and
Kaplan, G. Tumor necrosis factor alpha is a determinant of
pathogenesis and disease progression in mycobacterial infection in
the central nervous system. Proc. Natl. Acad. Sci. USA 96:
5657-5662 (1999).
- Murray, P.J., Aldovini, A. and Young, R.A. 1996. Manipulation
and potentiation of antimycobacterial immunity using recombinant
BCG secreting cytokines. Proc. Natl. Acad. Sci. USA 93:
934-939.
- Aldovini, A. and Young, R.A. 1991. Humoral and cell-mediated
immune responses to live recombinant BCG-HIV vaccines. Nature 351:
479-482.
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