Human Macrophage Activation Programs Induced by Bacterial Pathogens

This site supports Nau, et al., Proc. Natl. Acad. Sci. USA 99:1503-1508 (2002).

Project Goals Background Cell Sources Technology Protocols Analysis

Gene Expression Data

Human Macrophage Expression Responses to Bacterial Pathogens Macrophage gene expression data Pro-inflammatory common signature Profiling of Macrophage Responses to Bacterial Components A subset of bacterial components elicit much of the common signature

Results and Insights

Macrophage activation programs are triggered by diverse bacteria TLR agonists can elicit the common signature Differences in expression profiles distinguish among bacteria M. tuberculosis represses IL-12 production

Supplementary Figures

1. Human Macrophage Gene Expression Changes in Response to Bacteria 2. Gene Expression of Primary Human Macrophages Relative to Human Fibroblasts 3. Macrophage Gene Expression in the Absence of Stimuli 4. Experiment- or Donor-specific Macrophage Gene Expression 5. Endotoxin Contamination is not Responsible for hsp-induced Cytokine Secretion 6. A TLR-4 Antagonist Inhibits Production of TNF-alpha by hsp70 7. E.coli MOI Has Minimal Effects on the Macrophage Gene Expression Signature