Young Lab :: Data Download

Data Download (Published and Unpublished)

Zhang et al. (2016) Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Hnisz et al. (2016) Activation of proto-oncogenes by disruption of chromosome neighborhoods

Soldner et al. (2016) Parkinson-associated risk variant in distal enhancer of a-synuclein modulates target gene expression

Saint-André et al. (2016) Models of Human Core Transcriptional Regulatory Circuitries

Ji et al. (2016) 3D Chromosome Regulatory Landscape of Human Pluripotent Cells

Oldridge et al. (2015) Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

D'Alessio et al. (2015) A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity

Sigova et al. (2015) Transcription factor trapping by RNA in gene regulatory elements

Hnisz et al. (2015) Activation of proto-oncogenes by disruption of chromosome neighborhoods

Ji et al. (2015) Chromatin profiling reveals novel proteins associated with histone-marked genomic regions

Wang et al. (2015) CDK7-dependent Transcriptional Addition in Basal-like Breast Cancer

Hnisz et al. (2015) Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

Mansour et al. (2014) An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Christensen et al. (2014) Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

Cassady et al. (2014) Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells

Dowen et al. (2014) Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes

Buganim et al. (2014) The developmental potential of iPSCs is greatly influenced by reprogramming factor selection

Cassady et al. (2014) Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells

Kwiatkowski et al. (2014) Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Anders et al. (2014) Genome-wide localization of small molecules.

Dowen et al. (2013) Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements. [GSE33346][GSE30919]

Hnisz et al. (2013) Super-Enhancers in the Control of Cell Identity and Disease.

Mansour et al. (2013) The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. [GSE29180] [GSE33850] [GSE26015]

Whyte et al. (2013) Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes.

Loven et al. (2013) Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers.

Sigova et al. (2013) Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. [GSE36799] [GSE41009] [GSM896920] [GSM896921]

Lin et al. (2012) Transcriptional Amplification in Tumor Cells with Elevated c-Myc.

Sanda et al. (2012) Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

Qin et al. (2012) The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Family Complex that Is Essential in Pluripotent Stem Cells and Early Development.

Whyte et al. (2012) Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Mullen et al. (2011) Master transcription factors determine cell-type-specific responses to TGF-Beta signaling.

Trompouki et al. (2011) Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration.

Wang et al. (2011) The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development.

Ceol et al. (2011) The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.

Novershtern et al. (2011) Densely interconnected transcriptional circuits control cell States in human hematopoiesis.

Kagey et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture.

Guenther et al. (2010) Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells.

Lengner et al. (2010) Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

Rahl et al. (2010) c-Myc Regulates Transcriptional Pause Release

Bienvenu et al. (2010) Transcriptional Role of Cyclin D1 in Development Revealed by a Genetic-Proteomic Screen

Bilodeau et al. (2009) SetDB1 Contributes to Repression of Genes Encoding Developmental Regulators and Maintenance of ES Cell State

Jenner et al. (2009) The Transcription Factors T-Bet and GATA-3 Control Alternative Pathways of T-Cell Differentiation Through a Shared Set of Target Genes

Juan et al. (2009) Mir-214-Dependent Regulation of the Polycomb Protein EZH2 in Skeletal Muscle and Embryonic Stem Cells

Guenther et al. (2008) Aberrant Chromatin at Genes Encoding Stem Cell Developmental Regulators in Human Mixed-lineage Leukemia [ChIP-Seq data here]

Seila et al. (2008) Divergent Transcription from Active Promoters. [Non-coding RNA Profiling]

Seila et al. (2008) Divergent Transcription from Active Promoters. [RNA PolII ChIP-Seq Data]

Creyghton et al. (2008) H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

Lopez-Bigas et al. (2008) Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation [H3K4 ChIP-on-chip Data]

Lopez-Bigas et al. (2008) Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation [RBP2 ChIP-on-chip Data]

Lopez-Bigas et al. (2008) Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation [U937 Differentiation Gene Expression Data]

Lopez-Bigas et al. (2008) Genome-wide Analysis of the H3K4 Histone Demethylase RBP2 Reveals a Transcriptional Program Controlling Differentiation [RBP2 Knockdown Gene Expression Data]

Marson et al. (2008) Connecting the microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells [Sequence Data]

Marson et al. (2008) Connecting the microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells [Array Data]

Cole et al. (2008) Tcf3 Is an Integral Component of the Core Regulatory Circuitry of Embryonic Stem Cells

Guenther et al. (2007) A Chromatin Landmark and Transcription Initiation at most Promoters in Human Cells

Zeitlinger et al. (2007) RNA Polymerase Stalling at Developmental Control Genes in the Drosophila Melanogaster Embryo

Zeitlinger et al. (2007) Whole-genome ChIP-chip Analysis of Dorsal, Twist and Snail Suggests Integration of Diverse Patterning Processes in the Drosophila Embryo

Boyer et al. (2006) Polycomb Complexes Repress Developmental Regulators in Murine Embryonic Stem Cells

Lee et al. (2006) Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Odom et al. (2006) Core Transcriptional Regulatory Circuitry in Human Hepatocytes

Palomero et al. (2006) Transcriptional Regulatory Networks Downstream of TAL1/SCL in T-cell Acute Lymphoblastic Leukemia

Pokholok et al. (2006) Activated Signal Transduction Kinases Frequently Occupy Target Genes

Schreiber et al. (2006) Coordinated Binding of NF-kB Family Members in the Response of Human Cells to Lipopolysaccharide

Boyer et al. (2005) Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

Guenther et al. (2005) Global and Hox-specific Roles for the MLL1 Methyltransferase

Jenner and Young (2005) Insights into Host Responses Against Pathogens from Transcriptional Profiling

Pokholok et al. (2005) Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast

Harbison et al. (2004) Transcriptional Regulatory Code of a Eukaryotic Genome

Odom et al. (2004) Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

Robert and Pokholok et al. (2004) Global Position and Recruitment of HATs and HDACs in the Yeast Genome

Ng et al. (2003) Targeted Recruitment of Set1 Histone Methylase by Elongating Pol II Provides a Localized Mark and Memory of Recent Transcriptional Activity

Zeitlinger et al. (2003) Program-specific Distribution of a Transcription Factor Dependent on Partner Transcription Factor and MAPK Signaling

Lee et al. (2002) Transcriptional Regulatory Networks in Saccharomyces cerevisiae

Ng et al. (2002) Genome-wide Location and Regulated Recruitment of the RSC Nucleosome-remodeling Complex

Simon et al. (2001) Serial Regulation of Transcriptional Regulators in the Yeast Cell Cycle

Wyrick et al. (2001) Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae: High-Resolution Mapping of Replication Origins

Ren et al. (2000) Genome Wide Location and Function of DNA-Binding Proteins

Nau et al. (2002) Human Macrophage Activation Programs Induced by Bacterial Pathogens

Geisberg et al. (2001) Yeast NC2 Associates with the RNA Polymerase II Preinitiation Complex and Selectively Affects Transcription In Vivo

Lee et al. (2000) Redundant Roles for the TFIID and SAGA Complexes in Global Transcription

Robertson et al. (2000) The Yeast A Kinases Differentially Regulate Iron Uptake and Respiratory Function

Kobor et al. (1999) An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae

Wyrick et al. (1999) Chromsomal Landscape of Nucleosome-dependent Gene Expression and Silencing in Yeast

Holstege et al. (1998) Dissecting the Regulatory Circuitry of a Eukaryotic Genome

Unpublished Data

To View HDAC1, HDAC2, HDAC3, HDAC4, CCND2, and CDKN1B Chromatin Immunoprecipitation Data from MM1S Multiple Myelomoa cells, [September 2016]click here

To View CDK7, BRD4, and RNA Pol II Chromatin Immunoprecipitation Data from Jurkat T cell leukemia cells treated with JQ1 and THZ1, [June 2016] click here

To View RNA Pol II data in Jurkat cells, [August 2015] click here

To View H3K27ac, CTCF, E2F4, RNA Pol II and ZNF92 Chromatin Immunoprecipitation Data from Retinal Pigment Epithelial cells, [August 2014] click here

To View Med1, H3K27ac, and Sox2 Chromatin Immunoprecipitation Data from AD12, MEF, and Neural Precursor cells, [August 2014] click here

To View RNA Pol II, CDK7, and CDK8 Data in mouse ES cells and Jurkat cells, [August 2014] click here

To View Brd4, and RNA PolII Chromatin Immunoprecipitation Data from LY1 cells treated with 500nM JQ1 for 6hr, [December 2013] click here

To View H3K27ac and CDK8 Chromatin Immunoprecipitation Data from Colo741, HT29, and SW480 cells, [December 2013] click here

To View Brd4, Cdk9, Med1, and RNA PolII Chromatin Immunoprecipitation Data from H2171, MM1.S, and U87 cells, [July 2013] click here

To View Brd4, Cdk7, H3K9ac, H3K14ac, Med1 Chromatin Immunoprecipitation Data from Melanoma, MM1.S, and MV4;11 Cells , [April 2013] click here

To View Brd4, Cdk9, cMyc, Max, Med1, RNA PolII, H3K4me3 and H3K27Ac Chromatin Immunoprecipitation Data from MM1.S cells treated with 500nM JQ1 for 24hr, [November 2012] click here

To View Brd4, c-Myc, Max, Med1, RNAPII, and H3K27Ac Chromatin Immunoprecipitation Data from P493-6 cells, [November 2012] click here

To View H3K4me3, H3K27me3, and RNA PolII Chromatin Immunoprecipitation Data from Human Embryonic Stem Cells during endodermal differentiation, [September 2012] click here

To View cMyc and Max Chromatin Immunoprecipitation Data from Human Small Cell lung carcinoma cells expressing low or high levels of cMyc, [September 2012] click here

To View TAL1, HEB, E2A and GATA3 Chromatin Immunoprecipitation Data from Human T-cell acute lymphoblastic leukemia line RPMI-8402, [July 2012] click here

To View H3K4me3 and H3K27me3 Chromatin Immunoprecipitation Data from Human Induced Pluripotent Stem M23F cells Cells, [July 2012] click here

To View Smc1, Nipbl and Whole Cell Extract Chromatin Immunoprecipitation Data from Lymphoblastoid Cells, [June 2012] click here

To View Brd4, SA1, SA2, and RNA PolII (treated with JQ1 or Rretinoic Acid) Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells, [May 2012] click here

To View HOXA9 and MEIS1 Chromatin Immunoprecipitation Data from SEM Acute Lymphoblastic Leukaemia Cells, [May 2012] click here

To View CapH2, CapD3, RNA PolII Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells treated with and without Nocodazole, [March 2012] click here

To View SetDB1 and Whole Cell Extract Chromatin Immunoprecipitation Data from Melanoma cells, [March 2012] click here. For previously published Melanoma data click here

To View H2Bub, H3K9,K14Ac H3K4me3, Brg1, SA1 and SA2 Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells, [March 2012] click here

To View RNA PolII Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells treated with flavopiridol after DISF and NELF knockdowns, [December 2010] click here

To View H3K4me3, H3K27me3 and H3K9me3 Chromatin Immunoprecipitation Data from Mouse Embryonic Fibroblasts, [December 2010] click here

To View H3K9me3 Chromatin Immunoprecipitation Data from Mouse Secondary Fibroblasts, [December 2010] click here

To View MCAF1, REST, and H4K20me3 Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells, [December 2010] click here

To View E2F4, H3K27me3 and RNA PolII Chromatin Immunoprecipitation Data from Mouse Secondary Fibroblasts, [October 2010] click here

To View Whole Cell Extract Chromatin Immunoprecipitation Data from Mouse Secondary Fibroblasts, [October 2010] click here

To View H3K27me3, H3K79me2, and Suz12 Chromatin Immunoprecipitation Data from Human Embryonic Stem Cells, [October 2010] click here

To View Histone H3 Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells, Myotubes and Pro-B cells, [September 2010] click here

To View H3K4me3, H3K27me3 and H3K9me3 Chromatin Immunoprecipitation Data from Mouse estrogen-inducible MyoD1 Fibroblasts, [July 2010] click here

To View H3K4me3, H3K27me3 and RNA PolII Chromatin Immunoprecipitation Data from Human Jurkat cells, [July 2010] click here

To View H3K79me2 Chromatin Immunoprecipitation Data from Mouse Embryonic Fibroblasts, [June 2010] click here

To View RNA PolII Chromatin Immunoprecipitation Data from Mouse Embryonic Fibroblasts, [June 2010]] click here

To View TBP Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells, [June 2010] click here

To View Whole Cell Extract Chromatin Immunoprecipitation Data from Mouse Embryonic Fibroblasts, [June 2010] click here

To View Oct4 Chromatin Immunoprecipitation Data from Human Embryonic Stem Cells, [May 2010] click here

To View RNA PolII phospho Ser7 Chromatin Immunoprecipitation Data from Mouse Embryonic Stem Cells, [May 2010] click here

To view Ash1 Chromatin Immunoprecipitation Data in mES Cells, [November 2009] click here

To view H3K9K14Ac Chromatin Immunoprecipitation Data in mES Cells, [November 2009] click here

To view Pol2S5 Chromatin Immunoprecipitation Data in mES Cells, [November 2009] click here

To view Pol2 Chromatin Immunoprecipitation Data in SEM Cells, [November 2009] click here

To view H3K4me3 Chromatin Immunoprecipitation Data in REH Cells, [November 2009] click here

[publications (pubmed database)]

[[back to top]]